منابع مشابه
Humanization of antibodies.
Humanization has played a fundamental role in the remarkable progress of antibodies as therapeutic reagents. Here we have reviewed the publications on antibody humanization since the first report on CDR grafting in the second half of the 1980's up to June 2007. We describe the two main trends in the field: rational and empirical methods to humanize antibodies. Rational methods rely on the so-ca...
متن کاملAntibody Humanization Techniques
Antibodies are proteins with very important functions in the immune system. Thanks to their ability to recognize specific sequences from pathogens and other threats, antibodies can participate in the recognition and removal of foreign threats, such as virus and bacteria (Janeway et al.). Every human body is able to create millions of slightly different antibodies; every antibody has the ability...
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Time series representation is one of key issues in time series data mining. Time series is simply a sequence of number collected at regular interval over a period of time and obtained from scientific and financial applications. The nature of time series data shows characteristics like large data size, high dimensional and necessity to update continuously. With the help of suitable choice of rep...
متن کاملTabhu: tools for antibody humanization
SUMMARY Antibodies are rapidly becoming essential tools in the clinical practice, given their ability to recognize their cognate antigens with high specificity and affinity, and a high yield at reasonable costs in model animals. Unfortunately, when administered to human patients, xenogeneic antibodies can elicit unwanted and dangerous immunogenic responses. Antibody humanization methods are des...
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This thesis devises time-aware and trend-based ranking techniques. The time-aware techniques exploit temporal information, present in networks like the World Wide Web, to produce rankings reflecting authority with regard to a temporal interest. The trendbased techniques produce rankings based on the relative change of authority with regard to a temporal interest. We describe mathematics behind ...
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ژورنال
عنوان ژورنال: Journal of Technology and Information
سال: 2009
ISSN: 1803-537X,1803-6805
DOI: 10.5507/jtie.2009.004